Kwiminyaka yakutshanje, uphando kwiBenzylamino Acids(Benzylation of Amino Acids) iye yatsala ingqalelo ebanzi.I-Benzylamino acid yindlela yokwenziwa kweekhemikhali, enokuthi ifezekise utshintsho olusebenzayo ngokuzisa amaqela e-benzyl kwii-amino acid molecules, kwaye inethuba elibanzi lokusebenzisa.Ii-amino acids zezona zakhiwo zisisiseko zeeprotheni, kwaye iipropathi zazo kunye nezakhiwo zibalulekile ekusebenzeni kweeprotheni.Ngokuzisa amaqela e-benzyl, iimpawu ze-physicochemical ze-amino acid molecules ziya kutshintshwa, ngaloo ndlela zandisa ukusetyenziswa kwayo kwiinkalo zonyango, isayensi yezinto eziphathekayo kunye ne-organic synthesis.
Kwintsimi yeyeza, uphando malunga ne-phenylmethyl amino acid isetyenziswa ngokubanzi kwi-chiza synthesis.Ukukwazi kwayo ukwazisa amaqela e-benzyl kunika iimolekyuli zamachiza kunye nesakhiwo esizinzileyo kunye nethuba lokuphucula ukuxhamla kwabo.I-hydrophilicity kunye ne-lipid solubility yeemolekyuli zamachiza zinokuhlengahlengiswa ngokuzisa amaqela e-benzyl, ngaloo ndlela kuphuculwe umsebenzi wabo we-pharmacological kunye ne-bioavailability.Oku kubonelela ngamathuba amaninzi okuphuhliswa kwamachiza amatsha kunye nokukhuthaza ukusungulwa kunye nophuhliso kwicandelo lamayeza.Ukongeza, i-phenylmethylamic acid nayo inoluhlu olubanzi lwezicelo ezinokubakho kwinkalo yesayensi yezinto.
Ngokulawula iimeko ze-synthesis, izinto zepolymer ezinemisebenzi ethile zinokulungiswa.Ukuqaliswa kwamaqela e-benzyl kunokulungelelanisa umsebenzi ongaphezulu kunye neempawu zomatshini wezinto eziphathekayo, ngaloo ndlela kuphuculwe ukusebenza kunye nokusebenza kwezinto.Oku kuneempembelelo ezibalulekileyo kuphuhliso lwemimandla efana nemathiriyeli yebhetri, ii-catalysts kunye nezinzwa.Ukongeza, ukuphuhliswa kwendlela ye-p-benzyl amino acid nayo idlala indima ebalulekileyo kwi-organic synthesis.Ukusebenzisa le ndlela, abaphandi banokutshintsha ngokuchanekileyo ukwakheka kweeamino acid molecules ukudibanisa i-organic compounds kunye nemisebenzi ethile, efana ne-intermediates yeziyobisi kunye neemolekyuli ezisebenzayo.Oku kubonelela ngeqonga elibanzi le-organic synthetic chemistry kunye nokukhuthaza uphuhliso oluqhubekayo lwe-organic chemistry.
Okwangoku, uchungechunge lweempumelelo ezibalulekileyo zenziwe kuphando lwe-p-phenylmethylamino acid.Kwelinye icala, ngokweendlela zokudibanisa, abaphandi bahlala bephucula iimeko zokusabela kunye neenkqubo ze-catalyst zokuphucula ukusebenza kakuhle kunye nokukhetha.Ngakolunye uhlangothi, ngokubhekiselele kwiinkalo zesicelo, indlela ye-phenylmethylamino acid isetyenziswe ngokubanzi ekufumaneni izidakamizwa kunye nesayensi yezinto eziphathekayo, kwaye iphumelele uluhlu lweziphumo ezibalulekileyo.Ngelizwi, uphando kunye nokusetyenziswa kwe-p-phenylmethylamino acid kuya kwenza igalelo elihle ekuphuhliseni isayensi kunye nobuchwepheshe.Ukusetyenziswa okutsha kwale ndlela akukhuthazi nje kuphela uphuhliso lwecandelo lamayeza, kodwa kwakhona kuzisa impumelelo entsha kunye nezinto ezintsha kwiinkalo zesayensi yezinto kunye ne-organic synthesis.Kukholelwa ukuba ngemigudu yabaphandi abaninzi, ukusetyenziswa kwe-phenylmethylamino acid kuya kubonisa ithemba elibanzi kwixesha elizayo.
Ixesha lokuposa: Aug-10-2023
